Bernd T. Schmeck

Research Area

The Schmeck lab studies regulatory networks in microbe-host interactions. Main interests are the molecular mechanisms underlying commensal and pathogenic bacteria-host interactions of gram-positive (Streptococcus pneumoniae) and gram-negative (Klebsiella pneumonia, Legionella pneumophila) model organisms. Specifically, we analyse the transcriptional and proteomic networks in parallel, in bacterial and host cells, and intercellular communication by extracellular vesicles.

Expertise

bacterial cell biology
extracellular vesicles
regulatory networks
microbe-host interactions
dual transcriptomics and proteomics
infection biology

Recent Publications

1. Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B. A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1. mBio. 2020 Mar 24;11(2). pii: e03155-19.

2. Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR. Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling. Nat Microbiol. 2019 Apr;4(4):701-713.

3. Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B. Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. J Infect Dis. 2019 Jan 29;219(4):540-543.

http://www.i-lung.de/

https://www.uni-marburg.de/en/fb20/departments/ciii/lung-research